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Welcome to Hotel Sempione

In the historical center of Florence, close to all major attractions

Discover our Hotel

Freshly redesigned hotel

Hotel Sempione in Florence

Hotel Sempione, unique in style and personality

Hotel Sempione, restyled in December 2013, is located in a privileged position in the heart of the historical center of Florence, just 200 meters from Santa Maria Novella train station and from Firenze Fiera Congress & Exhibition Center (Palazzo dei Congressi, Fortezza da Basso e Palazzo degli Affari).

The Duomo, the main Florentine museums (Uffizi Gallery and Accademia Gallery) and the major shopping districts are all just a stone-throw away from our hotel.

The Sempione offers each guest a unique experience of freshly redesigned hotel by its new owners Serena and Michele, who gave it a breath of new life in a chic and elegant, yet informal style.

Our rooms

Our 31 rooms are spacious, equipped with all the necessary amenities and offering a very pleasant and intimate atmosphere in a carefully modernized classic Tuscan style. Furthermore, the rooms are sound-proof to a good degree and are completely non-smoking.

Our hotel is also equipped with an elevator that connects the lobby with all the guest rooms.

Moreover, Hotel Sempione offers you a few budget rooms, more essential in terms of space but providing the same amenities as the standard rooms, plus two rooms with bathroom especially designed for our disabled guests.

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Bathrooms for disable guests


Wi-Fi Internet




Safety Deposit box



Fire Alarm




Shower or Bathtub

Courtesy Kit



Hotel Sempione is located in the heart of the historical center of Florence, a few steps away from the characteristic San Lorenzo market, Duomo and all most important Florentine museums.

At only 200 meters from the Santa Maria Novella train station, our hotel represents an ideal starting point for conveniently visiting all the major sights of Florence and all the elegant shopping streets, as well as being within walking distance from the Firenze Fiera Congress & Exhibition Center if you're coming here for business.

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